Biological Effects of Inhaled TiCl sub 4 /NH sub 4 OH Reaction Products in Sprague-Dawley Rats and Syrian Hamsters

摘要

Sprague-Dawley rats and Syrian hamsters were exposed for one hour to the reactant products of aerosolized TiCl sub 4 and NH sub 4 OH. Groups of each specie and sex were then immediately anesthetized (Point I) or maintained for 30 days (Point II) and blood samples taken for complete blood counts (CBC's) and clinical chemistry profiles (SMAC-20's). These animals were then sacrificed and complete autopsies were performed. There were no significant differences biologically in any of the CBC or SMAC-20's profile values for the exposed versus control animal groups at either Point I or II. One of the 30 exposed male hamsters (3%) at Point II developed multiple microgranulomas of the lung. (ERA citation 06:008275)