Critical Organ Concentration of Cadmium in Occupationally-Exposed Workers

摘要

This report describes the present Brookhaven facility for in vivo measurements of cadmium in man and provides a comparison with other portable systems. The cadmium detection limits are 2.2 mg in the kidney and 1.5 ppM in the liver for the Brookhaven system. In a recent field study, the cadmium content of the left kidney and concentration in the liver were measured in 82 occupationally exposed workers and 10 control subjects. Organ content ranged up to 57 mg in the kidney and up to 120 ppM in the liver for the industrial group. By contrast, the values for the control group ranged from 0.4 to 11.8 mg for the kidney and 0.7 to 7.9 ppM for the liver. The geometric means were 3.7 mg for the kidney and 2.7 ppM for the liver in the control group. When the data were analyzed to provide an estimate of the critical concentration for the kidney, a range of 300 to 400 mu g/g for the renal cortex was calculated. The corresponding cadmium concentrations in the liver and urine were 30 to 42 ppM (liver) and 22 to 28 mu g/g creatinine (urine), respectively. Blood and urine levels of cadmium and beta sub 2 -microgloubin were also evaluated as possible biological indicators of organ content. (ERA citation 06:017526)