Comprehensive Evaluation of Progress in the Area of Helix-Destabilizing Proteins

摘要

Single-stranded DNA binding proteins, which destabilize the DNA duplex in vitro, have been identified in all classes of biological systems. These proteins differ in structural and activity properties. While the helix-destabilizing protein of T sub 4 bacteriophage and E. coli have been assigned a clear function in vivo, for those from other sources unequivocal data pertaining to their function is lacking. It is clear that they must play a central role in molecular events at the genome level, but a great deal of detailed work remains to be done to define such a role. (ERA citation 07:051588)