Radionuclide Labelling of a Synthetic Heparin-Like Polyelectrolyte and the Adsorption of It onto Silicone Rubber

摘要

This report describes attempts to prepare a radionuclide labelled polyelectrolyte tracer of adequate stability and specific activity to study the formation and stability of polyelectrolyte coatings for use as blood compatible materials in medical practice. Two kinds of polyelectrolyte were used, both prepared from polyisoprene, and three different labelling procedures were investigated. exp 125 I and exp 35 S were shown to be inadequate tracers but tritium was stably incorporated in the polyelectrolyte molecule with a labelling yield better than 90%. This tracer was then used to perform measurements pertaining to the binding and release of polyelectrolyte by a silicone rubber surface. Irradiation with gamma rays was shown to induce binding. (Atomindex citation 14:792851)