Statistical Analysis of High SCE Frequency Cells in Human Lymphocytes

摘要

The existence of a subpopulation of lymphocytes in which genetic damage persists was identified in experiments on rabbits injected with low levels of mitomycin C. This led to the suggestion that an important parameter to quantify after exposure to a possibly harmful agent may be the proportion of cells with high sister chromatid exchange (SCE) frequency, i.e., high frequency cells (HFCs). In the research reported here we describe the statistical properties of HFCs, particularly their utility in detecting low levels of genetic damage which may be undetected by a simple t-test comparing the means of two samples of SCEs. (ERA citation 09:012863)