In Vivo Studies on Enhancement and Promotion of Respiratory Tract Carcinogenesis Studies with Heterotopic Tracheal Transplants

摘要

Although most of the in vivo work on respiratory tract tumor promotion does not fulfill the most strict and dogmatic requirements of the two-stage carcinogenesis model (probably because the initiating doses utilized have not been low enough), the available data do show an important enhancement of tumor production, which is still compatible with a promoting effect. The tracheal transplant system seems to be an adequate tool to continue these investigations. Especially the new methodological advances permitting a combined in vivo - in vitro evaluation of the effects of known amounts of carcinogens and/or promoters, the flow through tracheal implants and the human xenotransplanted epithelia offer an ideal set of conditions to study the effects of promoters and suspected promoters of probable importance in the development of human cancer. 30 references, 3 figures, 3 tables. (ERA citation 10:003481)