Cell Sensitivity to Irradiation and DNA Repair Processes. Oxygen Enhancement Ratio in Different Mutants of Escherichia Coli

摘要

A new model of oxygen effect realisation is proposed for E.coli cells. The model explains differencies in oxygen enhancement ratio (OER) between wild type cells and repair deficient mutants. These differencies are logically linked to corresponding defects in repair systems. A quantitative analysis has been performed. The dependence of OER and cell sensitivity on the properties of cultivation medium is considered, too. Decreasing OER and increasing sensitivity in poor conditions are explained as the consequence of the shift of repair capacity from slow to fast repair system. 42 refs.; 2 figs. (Atomindex citation 17:058863)