Disposition of (2-hexyl 14c) Di-(2-ethylhexyl) Phthalate in the Rat with Cover Letter dated 09/17/1984

摘要

The absorption, distribution and elimination of (2-hexyl 14C) di(2-ethylhexyl)phthalate (14C-DEHP) was studied in four male Sprague-Dawley rats administered 14C-DEHP by gavage at a nominal dose of 100 mg/kg of body weight. 61.5% of the radioactivity was recovered in the feces, of which 34% and 4% were unchanged DEHP and MEHP respectively. The remainder (29.9%) was eliminated in the urine in the form of metabolites and expired air as 14CO2 (3.7%). The excretion of expired 14CO2 was biphasic with an alpha-phase half-life of 3.1 hrs and a beta-phase half-life of 41.1 hrs.