Toward a Cell-Culture Model of Cancer

摘要

The spontaneous transformation of normal Chinese hamster cells into malignant cells was studied. Hamster cells when grown in culture over an extended series of subcultivations inevitably become malignant even without exposure to a carcinogen. The study of this process using flow cytometry and the implantation of cultured cells into retrievable sponges placed under the skin of a nude mouse is described. (ERA citation 09:046631)