Cadmium Toxicity in Drosophila: Genetic and Physiological Parameters

摘要

We are searching for physicochemical characterizations of metal ions so that their mechanisms of toxicity in animals may be understood. As a consequence of understanding these mechanisms, the ability to predict the toxic reaction under new or different circumstances may become possible. In this study we examine: (1) correlation of the thermodynamic properties of some multivalent cations to thier acute toxicity in Drosophila and mice; (2) the genetic factors of Drosophila that pertain to resistance to cadmium and other toxic cations, and (3) physiological and biochemical responses of Drosophila to metal ions in the diet. 6 refs., 2 tabs. (ERA citation 11:028560)