Measurement of Unscheduled DNA Synthesis in Germ Cells of the Male Mouse (Mus Musculus)

摘要

An in vivo test was used to measure induced unscheduled DNA synthesis (UDS) in the germ cells of male mice exposed to the chemicals. Early spermatids, a DNA-repair competent stage, were used to test the effects of 2-acetylaminofluorene (2-AAF), 4-acetylaminofluorene, (4-AAF), benzopyrene (BP), pyrene (PYR), and methyl methanesulfonate. Neither the two ''carcinogens'', 2AAF and BP, nor the two ''non-carcinogens'', 4AAF and PYR, induced a measurable response in the early spermatids at any exposure used. 15 refs., 7 figs., 7 tabs. (ERA citation 10:040263)