Boronated Dextran-Monoclonal Antibody Conjugates for NCT

摘要

Monoclonal antibodies (MoAbs) to tumor-associated antigens are attractive carriers for concentrating sup 10 B in target tissues. Since coupling of sup 10 B compounds directly to MoAb in amounts sufficient for radiotherapy appears to lead to inactive complexes, we have used detrans as intermediate carriers to allow high levels of sup 10 B to be carried by MoAbs while modifying fewer amino acid residues. Three to five periodate-oxidized dextrans have been attached to anti-IgM polyclonal (IgG) antibodies, followed by coupling of a benzylamine derivative of decachlorocarborane to the extent of ca. 1000 boron atoms per IgG molecule. 41 refs., 1 fig., 1 tab. (ERA citation 12:010027)