Female Fertility Study of Sprague-dawley Rats Exposed by Inhalation Route to Acetone Cyanohydrin with Cover Letter dated 04/25/1986

摘要

Fertility was evaluated in groups of female Sprague-Dawley rats (24/group) receiving whole body exposure to acetone cyanohydrin at nominal concentrations of 10, 30 or 60ppm in a dynamic air flow chamber, 6hrs/day, 7days/week for 21 days. On day 21, females were mated to untreated males and exposure was continued until copulation was confirmed. Females were sacrificed at mid-gestation (gestation days 13-15). There was no effect of treatment for all animals as indicated by mortality, body weights and necropsy observations. Female fertility parameter values were comparable between treatment groups and the control group for: mating efficiency, pregnancy rates, number of live implants and pre- and postimplantation losses.