Methods for Supercritical Fluid Chromatography-Mass Spectrometry: New Approaches

摘要

Supercritical Fluid Chromatography-Mass Spectrometry (SFC-MS) provides a significantly enhanced chromatographic efficiency per unit time compared to HPLC, and more than 3000 and 12,000 effective theoretical plates can be obtained with 50 mu m and 25 mu m (i.d.) columns, respectively. The mass spectrometer, with the ability to acquire both chemical ionization and electron ionization spectra, provides the basis for obtaining both high sensitivity and selectivity or structural information for identification of unknown materials.