Comparative Toxicity of Crude and Refined Coal Liquids and Analogous Petroleum Products. 1. Chronic Dermal Toxicity in Mice

摘要

Among the coal liquids tested, only the raw H-coal blend produced an essentially 100% incidence of skin tumors at all 3 concentrations tested. The first tumors were seen 10 weeks after the first application of 50 mu l of the undiluted material. With the lower concentrations, the first tumors were seen after 20 and 33 weeks, respectively. Once the first tumor was discovered in any group, it took approximately one year until most animals in a given group had developed skin tumors. Of these tumors, 46% were malignant squamous cell carcinomas. 1 tab. (ERA citation 11:021084)