Photophysics and Chemistry and PAH (Polycyclic Aromatic Hydrocarbons) Compounds: Progress Research Report.

摘要

Our work is relevant to (1) an understanding of the fundamental photophysical properties of PAH compounds, particularly photoionization, energy transport, and interactions at solid/electrolyte interfaces, and (2) the ultimate fate and biological impact of PAH compounds and their derivatives, particularly the interactions of the highly reactive metabolites with DNA; the latter is believed to be the key initial step in mutagenesis and the initiation of tumorigenesis. Research is discussed in the following: particulate photophysics, particularly the mechanisms of photoionization and photoemission of electrons from micron-sized particles; heterogeneous chemical reactions at particulate/gaseous interfaces; charge-carrier and exciton-induced chemical reactions at crystal/aqueous electrolyte solution interfaces; energy transport mechanisms in organic crystals utilizing the triplet state and its magnetic resonance properties as a probe; and early events in the interactions of PAH compounds and their metabolites in biological systems, as modeled by the interactions of highly reactive metabolite model compounds with DNA and other nucleic acids. These interactions produce biological damage and initiate long-range biological effects in living systems. 69 refs., 22 figs., 2 tabs. (ERA citation 13:054398)