Biology Division Progress Report for the Period of October 1, 1986-September 30, 1988.

摘要

The Biology Division of the Oak Ridge National Laboratory is one component of the Department of Energy's intramural program in life sciences. Accordingly, /approximately/75% of the Division's total budget is derived from the Department of Energy through its Office of Health and Environmental Research. With respect to experimental biology, the congressionally mandated mission of this Office is to study adverse health effects of energy production and utilization. Within this stated broad mission, common themes among the research programs of the Biology Division are interactions of animals, cells, and molecules with their respective environments. Investigations focus on genetic and somatic effects of radiation and chemicals. Goals include identification and quantification of these effects, elucidation of pathways by which the effects are expressed, assessment of risks associated with radiation and chemical exposures, and establishment of strategies for extrapolation of risk data from animals to humans. Concurrent basic studies in genetics, biochemistry, molecular biology, and cell biology illuminate normal life processes as prerequisites to comprehending mutagenic and carcinogenic effects of environmental agents. (ERA citation 13:057592)