General Theoretical Approach to Dose Response Modeling - Implications for Risk Assessment

摘要

The major point of this discussion is that it is unlikely that there exists a unique dose response relationship even for the simple case of a single toxic material in a single biological system. Different dose response relationships can be produced by varying the dose rate (which affects cellular alteration and killing rates) as related to cellular dynamics (turnover time) and repair rates. Thus, in extrapolation from high dose, high dose rate conditions, not only the magnitude of variables but also the fundamental nature of the dose response is being changed. In the general case, one must at least consider an n-dimensional dose response surface rather than a single curve presented in only 2 dimensions.