Biological (60)Co Radiation Effects on Mouse Embryos in the Presence of Sodium Selenite

摘要

A single dose of sodium selenite (0,5 mg Se/Kg b.w.) was injected intraperitoneally into mice on day 17 pregnancy, 2h before 1.5 and 3.0 Gy whole body gamma irradiation. Irradiation produced a growth impairment in the newborns. Weight improvement as a function of age offspring from irradiated mice decreased proportionally to applied dose. Administration of selenite results also in a decrease of growth rate. Nevertheless, when irradiation and selenite treatments were combined, no additive effect can be observed, suggesting that selenium pretreatment would exert some protection against radiation-induced retardation of growth. (Atomindex citation 20:018410)