New (Sup 191) Os/(Sup 191M)Ir Generator System for Medical Use.

摘要

The use of ultra-short lived single photon emitting radionuclides for angiography offers several advantages including the opportunity to perform rapid repeat studies and a significantly reduced radiation exposure to both patient and personnel. Considering the physical characteristics of the (sup 191) Os(sup 191)Ir radionuclide pair, a generator system based on this parent-daughter pair presents additional specific advantages. (sup 191m)Ir decays by isomeric transition with a half life of 4.96 sec emitting x-rays and gamma photons, which are compatible with conventional gamma cameras. The short half life of (sup 191m)Ir minimizes the absorbed dose by the patient and permits the injection of a bolus every 30 sec. The sup 191 Os parent decays by beta (sup -1) emission with a half life of 15.4 days emitting no gamma photons. The long half life of the (sup 191)Os parent makes the useful shelf life of the generator several weeks. A new (sup 191)Os/(sup 191m)Ir radionuclide generator system which utilizes a heat-treated activated carbon adsorbent has been developed. In the present paper, the preparation, the characteristics, and the use conditions of this generator are described. 4 refs., 2 figs., 1 tab. (ERA citation 14:011527)