Role of Telomere Dysfunction in Driving Genomic Instability

摘要

The National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) is nearing completion of construction and is preparing for the National Ignition Campaign (NIC) with potentially significant yield in 2010. The design of a wide range of yield diagnostics in and outside the target-bay of the NIF must consider scattered background neutrons and neutron-induced gamma rays to measure neutrons and x-rays from target. The large and complex target chamber and facility make the calculation of scattered neutrons and gamma rays extremely challenging. The NIF was designed with shielded locations for many of the yield diagnostics including the neutron alcove and four diagnostic mezzanines. Accurate calculation of the background levels in these shielded locations requires advanced Monte Carlo techniques, e.g., variance reduction. Placement, size, and materials of collimators on the line of sight (LOS) through the shielding must be evaluated to trade off signal levels and unwanted backgrounds. The background at these locations is also affected by neutrons that pass through the laser beam tubes and scatter off of structures and walls in the switch yards. Detailed 3D Monte Carlo analyses are performed to determine neutron and gamma fluxes for some of the yield diagnostics.