Toxicological Information for Hazard Evaluation: The Chemical Unit Risk Estimates Database.

摘要

Various health hazard assessments have been conducted as part of the overall effort to ensure safe application of chemical agents. Chemical carcinogenicity and health risk assessments are key scientific bases for regulatory actions, but methods for such assessments are relatively new and are still under development. Different experimental protocols can lead to conflicting results that could be misleading. Furthermore, expensive experimental evaluations and/or risk assessments are often performed repeatedly without reaching definitive conclusions. To ensure the best derived risk assessment values and to communicate research information, a comprehensive Chemical Unit Risk Estimates (CURE) database has been designed and implemented. CURE is an interactive, multifunctional database based on chemical records for the purpose of providing (a) a focal point for the collection and storage of health risk assessment numerically generated estimates that provides for side-by-side comparisons of various related risk estimates; (b) a tool for calculating numeric health risk estimates; (c) a research instrument to assist in document and methodology development; (d) an historical collection of estimates yielding a perspective of the development of RAD; and (e) an information management system for the US Environmental Protection Agency, Office of Health and Environmental Assessment documents. 4 refs., 3 tabs. (ERA citation 14:029537)