DNA Adduct Formation by Twelve Chemicals with Populations Potentially Suitable for Molecular Epidemiological Studies

摘要

The feasibility of an epidemiological study using molecular biomarkers or adducts as quantitative measures of exposure and predictors of adverse health effects depends on several variables. This manuscript focuses on how adducts are formed and whether they are stable long enough to be detected; and the degree of understanding of the relationship between the biomarker and the specific biological response of concern (e.g., carcinogenesis, mutation, etc.). Selection of the chemicals---eight individual chemicals and a group of three benzidine-related chemicals---was made by comparing potential study population quality and availability with DNA adduct information from two lists (94 chemicals reported to form DNA adducts and 283 chemicals taken from the EPA/HERL genotoxicity list). A novel approach to population analysis was used to put priorities on the chemicals for review. 218 refs., 23 tabs. (ERA citation 14:016150)