Assembly and Analysis of Short-Term Genotoxicity Test Data: An ICPEMC Committee 1 Working Paper.

摘要

Several years ago, ICPEMC Committee 1 set out to improve this situation by designing a method to compile and interpret short-term test data. The driving principle was to combine the major entries of testing (dose, metabolic activation, sign of response and the replication of test data) into a single score which could be pooled by entry, by test (e.g., Salmonella reverse mutation), by test class (e.g., bacterial mutation) and by family (in vitro or in vivo), into a composite score for a chemical. The system is designed (i) to cope with redundant data, disagreement, and sporadically filled matrices, (ii) to supply statistical properties by chemical and by test, and (iii) to have features of self-learning to improve predictive performance and internal consistency for any one of several types of genetic hazard, including genotoxicity per se, carcinogenicity and reproductive toxicity. The system already appears to be a powerful analytical instrument to identify relationships between tests and chemicals. Like Genetic Activity Profiles as described by Waters et al., 1987, the system has the ability to provide a structure to test results, combine the tests into groups and to display this process graphically. 9 refs., 5 figs., 1 tab.