Dermal Corrosivitiy Study of C1328 Di-n-propylamine in Rabbits with Cover Letter.

摘要

Dermal irritation and corrosivity of Di-n-propylamine (142-84-7) was evaluated in 3 New Zealand White rabbits each administered 0.5 mL undiluted doses upon a single intact site of the right flank under semi- occluded patch. After 3 minutes, all patches were removed and the application sites cleansed of any residual test material for grading of signs of irritation and corrosion at 3 minutes, 1, 24, 48, 72 hours, and 7 days after initiation of the exposure. Initial necrosis that was noted in all animals at the 3-minute evaluation progressed to eschar documented in 2/3 upon the 1-hour examination and 3/3 rabbits upon the 24-hour examination. Slight to moderate edema, persisting in all animals, had diminished by 7th day study conclusion.