Mutagenicity Evaluation of Pyro-chek 77b Lot Iv213 (final Report) with Cover Sheet dated 030990.

摘要

Ethylene bis(pentabromophenoxide) was evaluated for mutagenicity by plate assay in two microorganisms, Saccharomyces cerevisiae, strain D4, and Salmonella typhimurium, strains TA1535, TA1537, TA1538, TA98, and TA100, both in the presence and absence of adult human male liver homogenate. Positive (MNNG, NF, QM, ANTH, AAF, and AMQ) and solvent (DMSO) controls were utilized. Test concentrations ranged from 0.1 to 500 ug/plate; the low dose was less than that which demonstrated any toxic effect, and the high dose produced quantitative or qualitative evidence of some chemically-induced physiological effects. No evidence of mutagenicactivity from ethylene bis(pentabromophenoxide) was seen in any of the assays conducted in this evaluation.