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Comparison of three physiologically-based pharmacokinetic models of benzene disposition.

机译：比较三种基于生理学的苯配置药代动力学模型。

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We assess the goodness of fit of three physiologically-based models of benzene pharmacokinetics to experimental data in Fischer-344 rats. These models were independently developed and published. Large differences in the quality of the fit are observed. In ...

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作者
F. Y. Bois T. J. Woodruff R. C. Spear;
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年度 1990
页码 1-24
总页数 24
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Animal Tissues; Benzene; Biological Localization; Carcinogenesis; EDB/550500; EDB/560300; Inhalation; Kinetics; Laboratory animals; Mathematical Models; Metabolism; Monte Carlo Method; Parametric Analysis; Pharmacokinetics; Pharmacology; Physiology; Rats; Regression Analysis; Risk Assessment; Statistics; Tables(data); Theoretical Data; Validation;

机译：动物组织;苯;生物定位;癌变; EDB / 550500; EDB / 560300;吸入;动力学;实验动物;数学模型;代谢;蒙特卡罗方法;参数分析;药代动力学;药理学;生理学;大鼠;回归分析;风险评估;统计;表（数据）;理论数据;验证;

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Comparison of three physiologically-based pharmacokinetic models of benzene disposition.

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