Initial Submission: Preliminary Information Indicating Adenomatous Polyps in an Inhalation Study of Hydrazine.

摘要

Hydrazine (CAS# 302-01-2) was evaluated for carcinogenicity. The test substance was administered to rats (sex, strain, and number not reported) at a concentration of 750 ppm for 1-hour/week for 10 weeks. Non-malignant lesions in the nasal tissue was detected in the treated animals indicating regenerative compensation. Also, a treatment-related incidence of hyperplasia or adenomatous polyps in 15 or 16 animals out of 600 animals was observed.