Effects of Liquid Storage and Cryopreservation on Platelet Surface Glycoproteins, Light Scatter, and Procoagulant Activity

摘要

The availability of monoclonal antibodies directed against well characterized functional platelet receptors combined with the use of flow cytometry allows the rapid analysis of many aspects of platelet pathophysiology. Testing plateletpheresis products with a panel of antibodies will provide a comprehensive 'picture' allowing assessment of the overall quality. Addition of in vitro agonists allows the study of platelet responses that result in receptor modulation and binding of coagulation and adhesive proteins. Selective evaluation of a variety of platelet properties, many of which can be analyzed simultaneously given the multiple-parameter capabilities of flow cytometry, promises to lead to predictive assays of in vivo platelet survival and function.