Protein Kinase C Isozyme in Mammary Carcinogenesis

摘要

Protein kinase C (PKC) is a key signal transduction pathway for regulating cellgrowth and differentiation. Perturbations in the PKC signaling pathway are widely recognized to be important in carcinogenesis since PKCs are the major cellular receptors for tumor promoting phorbol esters. PKC is actually a family of distinct isozymes that catalyze phospholipid-dependent protein phosphorylation. The role of individual isozymes in cellular processes has not yet been defined. The goal of this proposal is to study the role of individual PKCs in regulating mammary tumor growth and metastatic conversion.