Dose-Response Correlation of Methadone and its Metabolite EDDP in Human Hair.Start of the Third Series and Analysis of the Samples of the Second Test Series

摘要

We were able to arrange for the patients of two further Methadon practices, thatof Dr. Sachtleben in Pirmasens and Dr. Lueg in Kaiserslautem, to take part in our study. They were treated in the same manner as described in our previous Technical Reports. In this new series, the applied sweat patches were generally well accepted. Up until now only one patient (L2) has complained about irritations from the last patch. Blood was drawn by the personnel of the two practices. Hair strands were cut and bleached in the same manner as described previously. One patient from Kaiserslautem agreed only to give sweat and blood samples, another quit the program after collection of sweat patches and bleaching and cutting of the first hair strand. Nevertheless, this subject could be convinced to give blood and a small hair sample from the bleached strand to evaluate her individual hair growth window.