In Vitro Dermal Absorption of Insensitive Munitions Explosive 101 (IMX- 101) and Components.

摘要

We studied in vitro dermal penetration of the newly developed munition, IMX-101 (Insensitive Munitions eXplosive) as whole composition and its individual components; 2-4-dinitroanisole (DNAN), 3-nitro-1,2,4,-triazole-5- one (NTO), and nitroguanidine (NQ) in static Franz diffusion cells. The penetration rate was calculated (micrograms/sq cm/hr) for each chemical. The analysis of absorbed chemical in the receptor fluid data showed that steady state of fluxes infinite dose (100 mg) of neat NTO, DNAN, and NQ were 338.2, 1.1, and 31.3 micrograms/sq cm/hr, respectively. The IMX-101 powder (100 mg) had a rate of flux for NTO, DNAN, and NQ were 135.9, 1.18, and 236.3 micrograms/sq cm/hr, respectively. The penetration of IMX-101 (10 mg) with Tyvek showed the penetration flux of NTO, DNAN, and NQ were 102.5, 1.9, and 46.4 micrograms/sq cm/hr, respectively. These estimated values in vitro human model will be used to evaluate health risk associated with dermal exposure.