Dermal Penetration of the Candidate Insect Repellent AI3-37220 in Swine andRabbits

摘要

The study was performed to measure the dermal absorption of %be candidate insectrepellent A13-3722O in swine and rabbits. Percutaneous absorption of C-labeled A13-3722O in swine measured 8 percent of the applied dose through 7 days. Urinary excretion was the major elimination pathway for absorbed chemical. No significant tissue deposition was observed. In rabbits, dermal absorption measured 70 percent in animals where the substance was washed off after 24 hours. When left on the rabbit skin for 7 days, absorption totaled 76 percent. No bioaccumulation was observed in rabbit tissues. Within the intended use of A13-37220 as a topical insect repellent, skin absorption in humans would be expected to be less than 8 percent of an applied dose. Evaporation of the material is likely to exceed 20 percent of the applied dose within the first 24 hours.