Acute Toxicity Evaluation of JP-8 Jet Fuel and JP-8 Jet Fuel Containing Additives

摘要

To reduce fuel fouling in current U.S Navy and Air Force aircraft systems and toprovide additional heat sink and thermal stability for future systems, the Air Force is developing an improved JP-8 jet fuel (JP-8 + 100). Two companies (Betz and Mobil) have developed additive packages that are currently being tested in aircraft systems. To determine if the additive packages will produce health effects for flightline personnel, acute testing was performed on JP-8 and the two JP-8 + 100 jet fuels. A single oral dose at 5 mg jet fuel/kg body weight to five male and five female F-344 rats, and a single dermal application of 2 g jet fuel/kg body weight applied to five male and five female NZW rabbits resulted in no deaths. No signs of toxic stress were observed, and all animals gained weight over the 14-day observation periods. Single treatment of 0.5 mL neat jet fuel to rabbit skin produced negative results for skin irritation. Guinea pigs tailed to elicit a sensitization response following repeated applications of the jet fuels. Inhalation vapor exposure to JP-8, JP-8 + 100 (Betz), and JP-8 (Mobil) were determined to be >3.43, >3.52, and >3.57 mg/L, respectively. LD% values for aerosol exposure to JP-8, JP-8 + 100 (Betz), and JP-8 + 100 (Mobil) were >4.44, >4.39, and >4.54 mg/L, respectively. Under the conditions of these tests, the additive packages did not potentiate the acute effects normally associated with JP-8 jet fuel exposures.