Efficient Scavenging of Superoxide Radical (02-) in Vitro and In Vivo

摘要

We have prepared manganic porphyrins, as mimics of SOD activity. Severalgeneralizations follow: (a) In vivo action may involve cycles of reduction by NAD(P)H, or GSH, and reoxidation by O2; whereas the in vitro cycle involves O2 in both reduction and oxidation steps. (b) Action of mimics on bacterial cells is only a rough indicator of their action on mammalian cells; because of differences in uptake of the compounds. (c) Redox potential is more important than net charge, for activity in the in vitro assay. The most active compound we have prepared to date is the Mn(III) 2,3,7,8,12,13,17, 18-octabromo-5, 10, 15,20-tetrakis (N-methyl pyridinium-4-yl)porphyrin. Since the electron withdrawing effect of Br