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PCR and Mammalian Cell Selection Assays for Short-Term Genotoxicity TestingBackground

机译：用于短期基因毒性测试的pCR和哺乳动物细胞选择分析背景

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In order to develop an extremely sensitive test for chemicals that inducechromosomal rearrangements, a polymerase chain reaction (PCR) assay has been

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作者
Ehrlich, M.;
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年度 1996
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总页数 30
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Mammals; Toxicity; Deoxyribonucleic acids; Cells(Biology); Chain reactions; Testand evaluation; Detection; Risk; Chemicals; Molecules; Polymerization; Sensitivity; Defects(Materials); Selection; Assaying; Genetics; Adults; Nuclei; Cancer; Blood volume; Bl;

机译：哺乳动物;毒性;脱氧核糖核酸;细胞（生物学）;链式反应;测试和评价;检测;风险;化学品;分子;聚合;敏感性;缺陷（材料）;选择;测定;遗传学;成人;细胞核;癌症;血容量; BL;

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专利

1. Reduction of misleading ("false") positive results in mammalian eel genotoxicity assays. Ill: Sensitivity of human cell types to known genotoxic agents [J] . Paul Fowler, Robert Smith, Katie Smith, Mutation Research - Genetic Toxicology and Environmental Mutagenesis . 2014,第11期

机译：在哺乳动物鳗鱼遗传毒性试验中减少误导性（“假”）阳性结果。疾病：人类细胞类型对已知遗传毒性药物的敏感性
2. Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus). [J] . Galloway S, Lorge E, Aardema MJ, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2011,第2期

机译：研讨会总结：体外哺乳动物细胞遗传毒性测定的最高浓度;工作组的报告，介绍了体外细胞遗传学测定（染色体畸变和微核）的毒性测定和最高浓度。
3. Evaluation of the genotoxicity induced by the fungicide fenarimol in mammalian and plant cells by use of the single-cell gel electrophoresis assay. [J] . Poli P, de Mello MA, Buschini A, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2003,第1期

机译：通过使用单细胞凝胶电泳分析评估杀真菌剂苯那莫尔在哺乳动物和植物细胞中引起的遗传毒性。
4. Toxicity and genotoxicity studies of surface and waste water samples using a bacterial SOS/umu test and mammalian MTT and comet assay [C] . B. Zegura, E. Heath, A. Cernosa, International Conference on Environmental Toxicology . 2006

机译：使用细菌SOS / UMU试验和哺乳动物MTT和COMET测定的表面和废水样品的毒性和遗传毒性研究
5. The measurement of cell survival, and genotoxic endpoints in mammalian cells. [D] . Hook, Graham John. 1983

机译：哺乳动物细胞中细胞存活率和遗传毒性终点的测量。
6. A quantitative PCR-based assay reveals that nucleotide excision repair plays a predominant role in the removal of DNA-protein crosslinks from plasmids transfected into mammalian cells [O] . Lisa N. Chesner, Colin Campbell -1

机译：基于定量PCR的测定表明核苷酸切除修复在从转染至哺乳动物细胞的质粒中去除DNA-蛋白质交联中起主要作用
7. Evaluation of the genotoxicity induced by the fungicide fenarimol in mammalian and plant cells by use of the single-cell gel electrophoresis assay [O] . P Poli, M.A de Mello, A Buschini, 2003

机译：用单细胞凝胶电泳测定法评价哺乳动物和植物细胞中杀菌剂芬兰诱导的遗传毒性

PCR and Mammalian Cell Selection Assays for Short-Term Genotoxicity TestingBackground

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