Neural Responses to Injury: Prevention, Protection, and Repair. Volume 8. Vision, Laser Eye Injury, and Infectious Diseases

摘要

Four specific aims were proposed in the original grant application. Develop a new confocal microscope that can be used in living eyes to understand the earliest stages of trauma, laser injuries, and disease. We believed that a compact, portable confocal microscope could be developed that will replace the slit lamp biomicroscope and ophthalmoscopes which are used in routine ophthalmic exams, and which will provide much more needed information about laser damage, trauma, and other diseases in soldiers. Evaluate drugs to prevent retinal damage after laser injury. The pathogenesis of damage by trauma and laser is poorly understood. Pain and damage can disable people hours after injury, and being able to assess damage immediately will permit the appropriate assignment of personnel and aid in the prediction of subsequent disability. We proposed to use the confocal microscope to study eye damage after laser injury and to evaluate drugs such of calcium channel blockers, glutamate inhibitors, and PAF inhibitors for their effects on preventing and treating laser damaged tissue. Study traumatic and non-traumatic glaucoma to determine its pathogenesis. Glaucoma occurs as the result of trauma, as well as the result of an inherited condition. We proposed to use the confocal microscope to determine whether the outflow of fluid inside the eye has been changed, and to follow changes in the optic nerve, retinal vessels, nerve fiber layers, and in the gang lion cells.