首页> 美国政府科技报告 >Spontaneous Mutation in kdsD, a Biosynthesis Gene for 3-Deoxy-D-manno-Octulosonic Acid, Occurred in a Ciprofloxacin Resistant Strain of Francisella tularensis and Causes a High Level of Attenuation in Murine Models of Tularemia.

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Spontaneous Mutation in kdsD, a Biosynthesis Gene for 3-Deoxy-D-manno-Octulosonic Acid, Occurred in a Ciprofloxacin Resistant Strain of Francisella tularensis and Causes a High Level of Attenuation in Murine Models of Tularemia.

机译：kdsD（3-Deoxy-D-manno-Octulosonic acid的生物合成基因）的自发突变发生在土拉弗朗西斯菌的环丙沙星抗性菌株中，并导致小鼠Tularemia模型的高度衰减。

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Bozue, J. A.; Chance, T.; Chua, J.; Toothman, R. G.; Ladner, J. T.; Nuss, J. E.; Raymond, J. L.; Biot, F. V.; Demons, S.; Miller, L.; Mou, S.; Koroleva, G.; Lovett, S.; Palacios, G.; Vietri, N.; Worsham, P.; Cote, C.; Kijek, T.;
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年度 2016
页码 1-64
总页数 64
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正文语种 eng
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1. Evaluation of Francisella tularensis pdpC as a candidate live attenuated vaccine against respiratory challenge by a virulent SCHU P9 strain of Francisella tularensis in a C57BL/6J mouse model [J] . Tian Deyu, Uda Akihiko, Park Eun-sil, Microbiology and Immunology . 2018,第1期

机译：在C57BL / 6J小鼠模型中，FRANCISELA TULLENTESIS PDPC作为候选病毒症患者的候选病毒攻击症状的患者
2. A Francisella tularensis Live Vaccine Strain (LVS) Mutant with a Deletion in capB, Encoding a Putative Capsular Biosynthesis Protein, Is Significantly More Attenuated than LVS yet Induces Potent Protective Immunity in Mice against F. tularensis Challenge [J] . Qingmei Jia, Bai-Yu Lee, Richard Bowen, Infection and immunity . 2010,第10期

机译：带有假定的荚膜生物合成蛋白的capB缺失的tB弗朗西斯菌活疫苗株（LVS）突变体比LVS显着减弱，但可诱导小鼠抵抗Tularular挑战的有效保护性免疫力。
3. A Heterologous Prime-Boost Vaccination Strategy Comprising the Francisella tularensis Live Vaccine Strain capB Mutant and Recombinant Attenuated Listeria monocytogenes Expressing F. tularensis IglC Induces Potent Protective Immunity in Mice against Virulent F. tularensis Aerosol Challenge [J] . Qingmei Jia, Richard Bowen, Jacob Sahakian, Infection and immunity . 2013,第5期

机译：异源初免-加强免疫策略，包括土拉弗朗西斯菌活疫苗株capB突变体和重组减毒表达李斯特菌的单核细胞增生李斯特菌IglC诱导小鼠对抗强毒杜拉菌的强力保护性免疫力。
4. Generation and characterization of an attenuated mutant in a response-regulator gene of Francisella tularensis live vaccine strain (LVS). [D] . Sammons, Wendy L. 2007

机译：图拉弗朗西斯菌活疫苗株（LVS）的应答调节基因中减毒突变体的产生和表征。
5. A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia [O] . Taylor Chance, Jennifer Chua, Ronald G. Toothman, 2012

机译：kdsD（3种脱氧-D-甘露糖醛酸的生物合成基因）中的自发突变发生在耐环丙沙星的弗朗西斯菌的菌株中，并在鼠李糖血症小鼠模型中引起高度减毒
6. A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia. [O] . Taylor Chance, Jennifer Chua, Ronald G Toothman, 2017

机译：kdsD（3 Deoxy-D-manno-Octulosonic acid的生物合成基因）的自发突变发生在土拉弗朗西斯菌的环丙沙星抗性菌株中，并在鼠兔血症模型中引起高水平的减毒。

Spontaneous Mutation in kdsD, a Biosynthesis Gene for 3-Deoxy-D-manno-Octulosonic Acid, Occurred in a Ciprofloxacin Resistant Strain of Francisella tularensis and Causes a High Level of Attenuation in Murine Models of Tularemia.

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