Subchronic Physostigmine/Scopolamine Treatment in Guinea Pigs; Side-Effects andEfficacy against Soman

摘要

To prevent incapacitation following intoxication with irreversible cholinesterase(ChE) inhibitors, it has been proposed to replace the current pyridostigmine pretreatment by a pretreatment using a both peripherally and centrally active carbamate physostigmine (PHY). Unfortunately, PHY treatment may lead to incapacitating side-effects. In an earlier study, such side-effects were found