Selection and Characterization of Drug Resistant Variants of Human Immunodeficiency Virus

摘要

A major concern in the pursuit of effective therapies for human immunodeficiency virus (HIV) infection is the potential for HIV to develop drug resistance. The therapeutic efficacy of all currently licensed antiretrovirals is limited by the emergence of drug resistant HIV strains. Several promising new inhibitors of HIV reverse transcriptase (RT) and combinations of protease inhibitors are entering clinical trial, but inadequate information is available about the potential for HIV resistance to these therapies. The isolation and molecular characterization of drug resistant HIV variants that emerge in cell culture with drug selection has helped predict both the likelihood of resistance and the types of resistant mutants that appear in treated patients. Thus, the overall goal of this one year project was to continue to evaluate RT inhibitors for the development of HIV resistance.