Line-1 Retrotransposons as Mutagens in Human Breast Cancer

机译：Line-1反转录转座子作为人乳腺癌的致突变物

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The human LINE-1 retrotransposon (L1Hs) is known to cause mutations by insertinginto genes and inactivating them. The element is expressed in many breast tumors and breast mor cell lines, suggesting that L1Hs-induced mutations may play some role in this malignancy. To test this hypothesis we plan to place a 'tagged' LlHs

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作者
Fanning, T. G.;
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年度 1997
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总页数 8
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Neoplasms; Mutagens; Breast cancer; Epithelium; Humans; Mutations; Plasmids; Genes; Hypotheses; Medical research; Cells(Biology); Mammary glands; Disease vectors; Retroviruses; Metastasis;

机译：肿瘤;致突变物;乳腺癌;上皮;人类;突变;质粒;基因;假设;医学研究;细胞（生物学）;乳腺;疾病载体;逆转录病毒;转移;

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1. AhR ligands reactivate LINE-1 retrotransposon in triple-negative breast cancer cells MDA-MB-231 and non-tumorigenic mammary epithelial cells NMuMG [J] . Biochemical Pharmacology . 2020,第期

机译：AHR配体重新激活三阴性乳腺癌细胞MDA-MB-231和非致瘤乳腺上皮细胞NMUMG中的Line-1 Retrotransposon
2. Expression of line-1 retrotransposon induced by environmental pollutants in breast cancer cells [J] . Miret N., Zappia D., Zarate L., Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2018,第期

机译：乳腺癌细胞环境污染物诱导的线-1转回的表达
3. Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells [J] . PatnalaR., LeeS.-H., DahlstromJ.E., Breast cancer research and treatment. . 2014,第2期

机译：LINE-1逆转座子编码逆转录酶的抑制作用调节乳腺癌细胞中细胞分化基因的表达
4. Applying evolutionary computation to understanding the insertion behavior of LINE-1 retrotransposons in human DNA [C] . Meade, A., Corne, Evolutionary Computation, 2000. Proceedings of the 2000 Congress on . 2000

机译：应用进化计算了解LINE-1逆转座子在人类DNA中的插入行为
5. Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon [D] . Callahan, Kathryn E. 2012

机译：人LINE-1逆转座子编码的第一个开放阅读框（ORF1）蛋白的结构和功能。
6. Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer [O] . Long Chen, Jane E. Dahlstrom, Arin Chandra, -1

机译：LINE-1逆转录转座子表达及其亚细胞定位在乳腺癌中的预后价值
7. Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells [O] . 2014

机译：LINE-1反转录转座子编码逆转录酶的抑制作用调节乳腺癌细胞中细胞分化基因的表达

Line-1 Retrotransposons as Mutagens in Human Breast Cancer

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