Residual Acetylcholinesterase Activity in the Basal Lateral Amygdala Following Soman-induced Status Epilepticus

摘要

The possibility that the loss of AChE reactivity in discrete brain regions may have differential importance for induction of status epilepticus was investigated. Rats were infused with the monosialoganglioside GM1, through a permanent cannula implanted intracerebroventricularly (i.c.v.) and connected to an osmotic minipump. Controls received saline infusions or were sham operated. Rats received soman or saline injections 4.0+/-0.5 days following GM1 infusions. ECoG recordings were monitored via transcardial perfusions with brains removed and processed for AChE histochemistry. These observations suggest that the loss of AChE reactivity in the BL may be a postmortem index of seizure severity following soman administration.