Cell Signaling by a Novel SH2 Domain Protein that is Overexpressed with Her2 inBreast Cancer

摘要

The goal of this project is to determine the role of the Src Homology 2 (SH2)domain protein, Grb7, in tyrosine kinase signal transduction. Grb7 is overexpressed in approximately 20% of breast cancers in combination with the HER2 receptor tyrosine kinase. Our initial goals of this project were to determine the role of Grb7 overexpression on breast cancer cell behavior as well as to identify proteins that interact with Grb7. Our initial studies have not indicated a specific phenotype induced by Grb7 overexpression or specific proteins that can associate with Grb7. In order to determine a function for Grb7, we are currently generating a mouse deficient in Grb7.