Advanced Development of Antiviral Prophylactics and Therapeutics (ADAPT) - Research Area 10.

摘要

The purpose of the proposed work is to continue the promising anti-hemorrhagic fever virus (HFV) drug discovery and lead optimization efforts previously initiated by Prosetta through significant advancement of at least two chemical series through the first critical steps toward filing a Investigational New Drug (IND) application: efficacy, safety and mechanism of action. This project will launch from the advanced platform of lead of optimization of five Prosetta-identified compounds and will progress through target identification and efficacy assessment in rodents. Two of these advanced compounds have very strong nanomolar-to-low micromolar activity against all four HFV families studied - Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae.