Toxicokinetics of O-Ethyl S- (2-Diisopropylaminoethyl) Methylphosphonothioate (+)-VX in Hairless Guinea Pigs and Marmosets - Identification of Metabolic Pathways

摘要

The toxicokinetics of (+)-VX and its metabolites are studied in male hairless guinea pigs for the intravenous (i.v.) and percutaneous (p. c. ) routes, and in marmosets for the i.v. route, in order to provide a quantitative basis for pretreatment and therapy of intoxications with this nerve agent. In this report the results obtained in the first year of the 3-year contract period are presented. A bioanalytical procedure for the enantiomers of (+)-VX was developed, involving normal phase HPLC on a Chiralcel OD stationary phase and electrochemical detection after post-column addition of electrolyte.