Catecholamine Secretion from Individual Cells

摘要

The dynamic processes of chemical communication at single biological cells will be measured based on recent advances in microanalytical chemistry made in this laboratory. Many cells, including neurons, communicate by secretion of chemical substances by exocytosis where substances are extruded into the extracellular space following fusion of the vesicle and plasma membranes. Ultramicroelectrodes provide sufficient chemical, spatial, and temporal resolution which enable individual exocytotic events to be resolved for cells which secrete catecholamines. Thus, this process can be monitored, manipulated, and understood in a way not previously possible.