Mouse Model for the Cloning of a Tumor Suppressor Gene Mutated in Sporadic Breast Cancer

摘要

Growth factors transmit their signal by binding a receptor and activating a cascade of downstream events that eventually leads to cellular proliferation; normal or abberant. With regard to the Wnt I wingless family of growth factors / oncogenes, little is known about the receptor(s) or reception mechanism(s) involved. The present study may shed light on a key piece of this puzzle and unravel how Wnts cause cellular growth, often leading to tumorigenesis.