Prevalence of Chlorpheniramine in Aviation Accident Pilot Fatalities, 1991-1996

摘要

Chlorpheniramine, a popular nonprescription antihistaminic, is known to cause drowsiness. This side effect has a potential to impair performance and to be a factor in accidents. Therefore, this study was conducted to establish the prevalence of this drug in pilot fatalities of aviation accidents. During fatal aircraft accident investigations, postmortem samples collected from the pilots at autopsy are submitted to the Civil Aeromedical Institute for toxicological evaluation, and the findings are maintained in a database. Those data were examined for the presence of chlorpheniramine in the fatalities, which occurred during a 6-year (1991-1996) period. It was determined that there were 47 (2.2%) accidents involving chlorpheniramine. In 16 of these cases, only chlorpheniramine was found, with the mean concentrations of 109 ngml (n = 4) in blood and 1412 ng/g (n = 12) in liver. Other drugs were also present in the remaining 31 cases, wherein the mean chlorpheniramine concentrations were 93 ng/ ml (n = 18) in blood and 747 ng/g (n = 12) in liver. Ninety-five percent of all the quantitative blood values were at or above the therapeutic (10 ng/ml) level, giving a 100 ng/ml (n = 21) blood mean level. The drug's mean concentration in the liver of all the cases was 1080 ng/g (n = 24). The average chlorpheniramine blood value was approximately 10 times higher than its therapeutic value. The presence of other drugs did not appear to significantly alter the blood level of chlorpheniramine, but no such correlation could be established with the hepatic value. The approximate 10-fold increase in the liver concentration, as compared with the blood value, was consistent with the general trend of the distribution of drugs in the hepatic compartment. However, the contribution of postmortem redistribution of the drug to alter its concentration cannot be entirely ruled out.