Common Pathways in the Toxicity of Structurally Diverse Xenobiotics

摘要

Information was obtained on the mechanistic sequence of events which occurs, and whether single or multiple regulatory points appear to be involved. Extensive information was obtained regarding the possible development of chemoprotective agents against structurally diverse environmental toxicants based on the use of antioxidants and free radical scavengers. In summary, the results will significantly contribute to our basic knowledge regarding the cascade of events which occurs following a toxic insult by structurally diverse xenobiotics. Finally, Information is being obtained on the ability of antioxidants/free radical scavengers and selected inhibitors to provide protection against these xenobiotics.