Synthesis of Tetraazacrown Ethers Containing Two 8-Hydroxyquinoline Side Arms

摘要

Four new tetraazacrown ethers containing two 8-hydroxyquinoline side arms were prepared first by reductive amination of 8-acetoxyquinolin-2-carbaldehyde with the appropriate tetraazacrown ether containing two microring NH functions. The resulting bis(8-acetoxy-1-quinoli nylmethyl)-substituted tetraazacrown ethers were treated with 10% aqueous KOH followed by acid to form the N,N'-bis(8-hydroxy- 2-quinolinylmethyl) substituted tetraazacrown ethers.